Natural Surfactant Combined with Beclomethasone Decreases Lung Inflammation in the Preterm Lamb
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چکیده
Background: Natural surfactant combined with beclomethasone decreases pulmonary oxidative stress in preterm lambs with respiratory distress syndrome (RDS). Objectives: To test the hypothesis that this occurs through a decrease in pulmonary inflammation. Methods: Preterm lambs received 200 mg/kg of natural surfactant or 200 mg/kg of natural surfactant combined with 400 or 800 g/kg of beclomethasone. Interleukin 8 (IL-8) and macrophage migration inhibitory factor (MIF) were assayed in bronchial aspirate samples and lung mechanics were evaluated. Results: IL-8 increased in all the groups, but the increase was lower in the groups treated with surfactant plus 400 and 800 g/kg of beclomethasone. MIF decreased in the surfactant group, did not vary in the surfactant plus 400 g/kg beclomethasone group, and decreased in the surfactant plus 800 g/kg beclomethasone group. MIF concentration was higher in the Received: December 13, 2010 Accepted after revision: April 29, 2011 Published online: September 15, 2011 Carlo Dani, MD Division of Neonatology, Careggi University Hospital University of Florence School of Medicine Viale Morgagni, 85, IT–50141 Firenze (Italy) Tel. +39 055 7947 428, E-Mail cdani @ unifi.it © 2011 S. Karger AG, Basel 0025–7931/11/0824–0369$38.00/0 Accessible online at: www.karger.com/res D ow nl oa de d by : 54 .7 0. 40 .1 1 12 /2 6/ 20 17 3 :3 4: 21 A M
منابع مشابه
Natural surfactant combined with beclomethasone decreases lung inflammation in the preterm lamb.
BACKGROUND Natural surfactant combined with beclomethasone decreases pulmonary oxidative stress in preterm lambs with respiratory distress syndrome (RDS). OBJECTIVES To test the hypothesis that this occurs through a decrease in pulmonary inflammation. METHODS Preterm lambs received 200 mg/kg of natural surfactant or 200 mg/kg of natural surfactant combined with 400 or 800 μg/kg of beclometh...
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